The first step of an abusive relationship: Take away their support network...
In the books, the International Statute of Wizarding Secrecy presumably has an exception for the immediate families of Muggle-born wizards. The families of Muggle-borns we meet in the books (Hermione, Lily) know plenty of stuff about magic. But outside of that, there's nothing. Worse, it's not common practice to tell Muggle-borns about their abilities before the year they enter Hogwarts. (And not from lack of ability to identify them earlier. All magical children are detected at birth.)
I'd be very surprised if there isn't a large achievement gap between Muggle-born and wizard-born students at Hogwarts and other schools. Muggle-borns are, at age 11, shoved into a new world they know nothing about, and to make it worse, they're not allowed to talk about it even with their closest friends.
Thus, even though the Statute doesn't have an explicit blood-purist ideology written into it, it's still designed from such a magical-world-centric point of view that it hurts the very people who are already hurt the most by prejudice and discrimination.
Does this remind you of anything from real life? Please answer in the comments!
(In the books, all the major characters who were raised by Muggles – Harry, Hermione, Lily, Tom Riddle – are quite successful at Hogwarts. This is consistent with the books' general pattern of ignoring the more insidious aspects of social injustice.)
Approximate readability: 9.95 (1171 characters, 243 words, 14 sentences, 4.82 characters per word, 17.36 words per sentence)
Comments
As for the success of muggleborns, I have these responses to those that you listed (don't worry, I'm only justifying Hermione and Riddle, and I shouldn't have to say that to keep you from assuming that this is a pro-Rowling tract. Warning: I'm using gendered language for all characters referred to as such by the author):
I always thought that Harry having absolutely no one at home was a little contrived - all his grandparents are apparently dead even though his parents were only 20 when they died, he has no friends because of Dudley, even though Harry and Dudley went to different schools, and if Dudley was bullying other kids then those other kids could be friends with Harry. I thought J K Rowling did that on purpose so that she wouldn't have to deal with Harry losing relationships back at home, so that it was logical that he'd just be happy at Hogwarts because anyplace would be better than his home environment. Harry and Tom Riddle have that in common in the books.
As for Hermione, I always wondered why she never mentioned any friends at home. I wondered if we were supposed to assume that she didn't fit in at home because she's so interested in reading and learning. In the first book, Hermione doesn't really make friends until after the troll incident, so maybe we're supposed to assume she didn't have many friends back at home. And if we do assume that, then Harry, Tom Riddle, and Hermione are all entering the school without having that support system from home in the first place, so not being able to tell anyone wouldn't be an issue. But there is a general sense of “Hogwarts is the awesomest place in the world,” that is shared by everybody - absolutely no one seems to be homesick or have issues adjusting to the new lifestyle or missing their friends from home, even though it's logical that muggle-born students especially would have these issues. And I think you're right that there would be an achievement gap. Hermione is smarter than most, but Harry definitely would have struggled more. And how could he be the youngest quidditch seeker of the century when the wizard-born kids grew up riding on toy broomsticks?